PhysForum Science, Physics and Technology Discussion Forums -> spread of cancer cells

Scientific Forums

LoFi version for PDAs

Help

Members

Calendar

Welcome Guest ( Log In | Register )

Resend Validation Email

PhysForum Science, Physics and Technology Discussion Forums -> Biology, Chemistry, Medicine, Other Sciences -> Medicine / Health

Add reply · Start new topic · Start new poll

spread of cancer cells, Full story at http://www.physorg.com/news78762425.html

LoFi version | Track this topic | Email this topic | Print this topic

mott.carl	Posted: Sep 30 2006, 11:16 AM Quote
Advanced Member Group: Members Posts: 1435 Joined: 26-August 06 Positive Feedback: 35% Feedback Score: -123	http://www.physorg.com/news78762425.html the cancer cells use the scissors through of combinations of enzimes that permit altere the cellular membrane through of inversion of voltage and ions the if cut to give way to enter in the blood vassels,its synthetize several enzimesto get fot tentatives,get whether couple the receptors of cells,and get to penetrate in the other,as diffuse,its proteivns and enzimes to can encounter the correct "key" to calculs it size,it index of growth,and get exchange substances and nutrients,as well as altere the chemics and eletric permeability to live in inospit ambient.all that if must it maleability and all "memory" of the normal cells-then think that exist "stem cell" that is,oncogens,that produces all the mechanism to the cells obtain all that need.then these oncogens stem cell have all capacity9WITH THE BREAK OF ITS HIDDEN VARIABLES)that permit it get win to all barrier moleculares and other.thence the reason of its have methastasis.are there hidden symmetris.
	Send PM · Send email ·

Matador	Posted: Jan 20 2012, 01:31 PM Quote
Advanced Member Group: Power Member Posts: 873 Joined: 11-August 09 Positive Feedback: 95% Feedback Score: 46	-------------------- Banned by Administration
	Send PM · Send email ·

Robittybob1	Posted: Jan 20 2012, 07:29 PM Quote
Advanced Member Group: Power Member Posts: 6062 Joined: 15-October 11 Positive Feedback: 0% Feedback Score: 0	http://www.physorg.com/news78762425.html good link.
	Send PM · Send email ·

Matador

Posted: Jan 20 2012, 10:43 PM

Quote

Advanced Member

Group: Power Member
Posts: 873
Joined: 11-August 09

Positive Feedback: 95%
Feedback Score: 46

Molecular scissors help cancer cells break out and spread
September 29, 2006

A University of Michigan research team has identified how cancer cells employ a sort of molecular scissors to cut their way out of tumors and begin spreading throughout the body.

QUOTE

This spread of cancer cells, called metastasis, marks a turning point in the progression of the disease, after which treatment and recovery become more difficult.

"We asked how cancer cells cut their way through tissues," said Stephen Weiss, Life Sciences Institute research professor and division chief, molecular medicine and genetics in the U-M Medical School. "They use what we call proteases, a type of molecular scissors. However, there are so many different types of these scissors encoded by the human genome, we wanted to focus our attention on finding the subset used by cancers."

In all forms of cancer, a hallmark of malignancy is the tumor's ability to penetrate the basement membrane, a specialized connective tissue that lines the internal and external surfaces of the body including blood vessels, nerves, muscle and fat. Of the more than 500 enzymes that could be used by cells as molecular scissors, the Weiss team found that three proteases, termed MT1-MMP, MT2-MMP and MT3-MMP, are the most likely candidates that regulate cancer cell invasion.

The tumor cells appear to use these three enzymes to cut their way through the basement membrane, thus allowing cancer cells access to blood vessels which act as conduits for the spread of malignant cells to distant sites in the body.

"These closely related proteases allow cancer cells to start eating through basement membranes and the surrounding tissues," Weiss said. "This is the first critical step in the malignant process and allows the rapid spread of cancer cells through the body."

By identifying this set of proteases, the studies by Weiss and his colleagues have provided the first known proof that a small set of genes and proteins may underlie the cancer cell metastatic process. While their work is still at an early stage, the researchers are attempting to develop new inhibitors of these proteases so that they could test their importance in animal models of human cancer.

"A cancer cell metalloprotease triad regulates the basement membrane transmigration program," by Kevin Hotary, Xiao-Yan Li, Edward Allen, Susan L. Stevens and Stephen J. Weiss, appears as an advanced online publication in the journal Genes & Development and in print on Oct. 1, 2006.

Source: University of Michigan

http://www.physorg.com/news78762425.html

You may as well post the info in here. I hate clicking links.

--------------------

Banned by Administration

Send PM · Send email ·

Capracus

Posted: Feb 3 2012, 12:31 PM

Quote

Advanced Member

Group: Power Member
Posts: 4934
Joined: 5-October 06

Positive Feedback: 75.56%
Feedback Score: 41

QUOTE (kenneth26 @ Feb 1 2012, 10:52 AM)

Useful information comes out through this post.

Are you referring to the previous posts on cancer pathology or the link to your soap website?

Send PM · Send email ·

Nudofan	Posted: Feb 6 2012, 02:32 AM Quote
Unregistered	Cancers enter the bloodstream in microscopic amounts Cancers can be caused by carcinogenic aromatics chemicals: BPA's, food additives, preservatives, pesticides, perfumes............................. Cancers can be caused by yet unknown undetectable viruses in the bloodstream. Cancers can be caused by UV radiation. Have soldiers returning home from war wounds shown a larger incidence of cancers down the track years later than unwounded soldiers? From `Massive Blood Transfusions'

« Next Oldest | Medicine / Health | Next Newest »