Life's Drive And Purpose, Choice Of Our Life's Purpose Is OURS

Science Marches On

Sleep Is A Biological Enigma?
and
Sleep Protects Against Traffic Accidents


A. From "A good night's sleep protects against parasites"

http://www.eurekalert.org/pub_releases/200...c-agn010709.php

- "Sleep is a biological enigma. Despite occupying much of an animal's life, and having been scrutinized by numerous experimental studies, there is still no consensus on its function".

- "When asleep, animals largely avoid....activities, and can thus allocate resources to the body's natural defenses."


B. Sleep made simple: it is an inherent Earthlife trait

- Every organiasm sleeps because its genes-genomes sleep. And sleep is innate for genes because genes, being the first organisms evolved on Earth, came into being, born, by the sun's radiation energy absorbed by RNA-conformations oligomers, and the newborn genes were active ONLY when exposed to sunlight, which was then their only usable energy. Thus sleep is an inherent Earthlife trait.

- When asleep in bed, drivers largely avoid activities, and can thus allocate resources to the body's natural defenses against traffic and other accidents.


Dov Henis

(Comments From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

Life's Manifest
http://www.the-scientist.com/community/pos...st/112.page#578

What is the effect of sleeping pills on life's drive and purpose?

Seems that sleeping pills are superfluous for humanity when it comes to life's drive and purpose.

Seems that ALL humanity, especially the Science Establishment Guilds, are born sleep-addicts and ignorance-addicts when it comes to comprehending the most important aspects of the nature of life and life's course and the consequent weight of their personal decisions on the purpose and course of their life...

Dov Henis

How do genes/genomes sleep?

More On Genes-Genomes Sleep

I googled "Dov Henis on sleep and circadian rhythm" and got a number of my posts citing examples of evidence of genes-genomes sun's energy absorption and sleep, f.e.

http://www.physforum.com/index.php?showtopic=14988&st=135&

http://www.physorg.com/news114872572.html

http://www.the-scientist.com/blog/display/55081/


Dov Henis

Correction: should be

http://www.physorg.com/news115053032.html


DH

Further Elaboration Of Horizontal Gene Transfer


"Structure mediating spread of antibiotic resistance identified"
http://www.eurekalert.org/pub_releases/200...t-sms010709.php


Horizontal (lateral) gene transfer is incorporation, in an organism, of genetic material from another organism without being the offspring of that organism (versus vertical transfer, when an organism receives genetic material from its ancestor). The transfer is by a 'secretion process', of elaborating and releasing materials from within a cell. This work elaborates the role of Type IV sub-system, a component of the secretion system.

'Mediate' is a transitive verb that means to effect by action as an intermediary, to transmit as intermediate mechanism or agency. Spread of antibiotic resistance proceeds by horizontal gene transfer, that produces extremely dynamic genomes in which substantial amounts of DNA are introduced into (and deleted from) the chromosome, by transformation or conjugation or transduction.

Nice work and elaboration. But I cringe involuntarily at references as 'DNA materials' to genes and/or genomes, and at implying that 'the cell' does anything. For me it has been obvious for many years that genes and genomes are organisms and that all structures within the outer cell membrane (OCM), including the OCM itself, are functional organs of the genes-genomes, that we are discussing the members (genes) of the spaceship (cell) team (genome)...


Dov Henis
(Comments From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

Life's Manifest
http://www.the-scientist.com/community/pos...st/112.page#578

Aging Not Approachable With Oversimplification
The Aging Chain
Aging genes age genomes age cells age cellular organisms And Vice Versa


A. "Sirtuin shown to control gene activity"
http://www.sciencenews.org/view/generic/id..._gene_activity_
A previously overlooked protein called SIRT6 provides some molecular clues to aging.

Chua’s and Chang’s groups together show that SIRT6 works with a master regulatory complex called NFkappa-B to govern activity of genes associated with aging, inflammation, immunity and metabolism. When SIRT6 is missing, NFkappa-B becomes hyperactive and turns up activity of aging-linked genes.

Mostoslavsky believes many important body systems are affected by SIRT6, but cautions that the enzyme is not necessarily an anti-aging protein. The mutant mice lacking the protein have severe metabolic disturbances that could account for premature aging. Researchers have not yet detected any change in SIRT6 levels or activity with age.

“Whether this has a role in the normal aging process, we still don’t have enough information to answer that,” he says.


B. Aging, lifetime and age

Aging = to become old, show the effects or the characteristics of increasing age, the increasing liferime. Thee effects and characteristics of not only the totality of the system but also of each and every component and components of the components of the system. The system is the totality of the components.

lifetime = the duration of the existence of a living being, an organism, or an inanimate thing, a material, star or subatomic particle.

age = the length of an existence extending from the beginning to any given time.


Dov Henis

(Comments From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

Life's Manifest
http://www.the-scientist.com/community/pos...st/112.page#578

Extra Extra, Read All About It,
Biological Evolution Discovered
By Mathematicians And Evolutionary Ecologist


A. From "Mathematicians show how beetles can share a niche"
http://www.sciencenews.org/view/generic/id...n_share_a_niche
New equations help solve decades-old puzzle of why one species does'nt always outcompete another.

Placing two species of flour beetle in the same jar of flour needn't always result in one species driving the other to extinction. A new mathematical model shows how sometimes these two competing species can coexist.

"It opens some questions about this dogmatic view in ecology...It reopens the issue of what you consider a niche to be."

In the novel illuminating case researchers noted a small evolutionary change in the traits of the beetles. They sometimes eat the eggs of their own species as well as those of closely related species. In this case they evolved to become more-voracious egg eaters.

Cushing and his colleagues designed a mathematical model that, unlike previous models, allowed the egg-eating trait to evolve — which affected the birth and death rates of each species. Neither species went extinct after more than 30 generations.

What makes this work very, very exciting, comments an evolutionary ecologist, is that it shows how just a tiny bit of evolution might actually explain the results... (end quotes)


B. What a thrilling scientific discovery!

How just a tiny bit of evolution might actually explain the results...the co-existence of competing species...

Wow! this may explain why in some niches some competing species struggle violently whereas in others they coexist thrivingly! And just think that this may apply to so many types and sizes of niches and to so many species! Wow! It may apply even to human societies!



Dov Henis

(Comments From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

Life's Manifest
http://www.the-scientist.com/community/pos...st/112.page#578

Culture, A Ubiquitous Biological Entity
http://www.the-scientist.com/community/posts/list/98.page

On Humans (And Other Materials) Evolution
And On The Sad State Of Life Sciences In 2009


Re "Stanford researchers show adaptation plays a significant role in human evolution"
http://www.eurekalert.org/pub_releases/200...u-srs011409.php


1) "For years researchers have puzzled over whether adaptation plays a major role in human evolution or whether most changes are due to neutral, random selection of genes and traits."

- I have been presenting evidence for years that adaptation, i.e. culture, is the driver of evolution of all life including human and, yes, of all other materials, and that genetic evolution is generally biased, not random.

2) "Geneticists at Stanford now...show adaptation, the process by which organisms change to better fit their environment, is indeed a large part of human genomic evolution."

- Shortly after retiring from industrial consulting (1956 - 1998) I started investigating the state of comprehension of the nature of life and of its evolution and I published evidence and conclusion that culture is the driver of all genomic evolution.

3) "Others have looked for the signal of widespread adaptation and couldn't find it...now...we were able to detect the adaptation signatures quite clearly"

- I found the evidence many years ago and presented it clearly in my postings.

4) "All genetic mutations start out random, but those that are beneficial to an organism's success in their environment are directly selected for and quickly perpetuate throughout the population, providing a uniform, traceable signature."

- NO NO NO. The drive of evolution is NOT RANDOM followed by survival selection. It is biased, as explained in my "Life's Manifest" and elaborated in my posts about the role of culture in evolution.

5) "Humans have a very complex history from traveling around the globe, and the human genome is also highly structured, making it complicated and difficult to work with, he said."

- The human genome, like all other genomes, is complicated, being a multi-genes organism, an organism that consists of a cooperative commune of the smaller Earth's primal organisms, namely of genes.

6)"Adaptation becomes widespread in the population very quickly," Petrov said. "Whereas neutral random mutation doesn't and would not have the selective sweep signature."

- Bravo. This happens to be a correct statement. Random mutations are mechanical accidents that the organism may or may not overcome to survive.


I stop here. No patience nor interest to continue picking at each of the following paras. Just sadly frustrated at The Sad State Of Life Sciences In 2009...


Respectfully yours,

Dov Henis

(Comments From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

Life's Manifest
http://www.the-scientist.com/community/pos...st/112.page#578

Rethought Unified Field Theory And Evolution


A. SN Special : Darwin turns 200
http://www.sciencenews.org/view/feature/id...arwin_turns_200
This special web edition of Science News includes expanded versions of articles from the magazine's print edition plus two additional features, all commemorating the 200th anniversary of the birth of Charles Darwin.


B. 22nd Century Conception Of Unified Field Theory And Evolution

The following brief essays present the 22nd century comprehension of evolution. They preserve Darwin's name in reference to Life Evolution in respect and appreciation of Darwin's promotion of the concept of evolution in life.

Life's Manifest
http://www.the-scientist.com/community/pos...st/112.page#578

Culture, A Ubiquitous Biological Entity
http://www.the-scientist.com/community/posts/list/98.page

Life And Darwinian Evolution, 21st Century Comprehension
http://www.the-scientist.com/community/posts/list/112.page

Rethink Unified Field Theory And Evolution
http://www.the-scientist.com/community/pos...60/122.page#982


Dov Henis

(Comments From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

What Is Switched When Genes Are Switched


A. "Gene switch sites found mainly on 'shores,' not just 'islands' of the human genome"
http://www.eurekalert.org/pub_releases/200...i-gss011209.php

CpG islands are DNA regions containing a high frequency of CpG (cytosine-phosphodiester-guanine) dinucleotides, 300-3,000 base-pairs long in mammalians, often in-near 'promoters' of mammalian genes.

"Epigenetic finding adds insight on how cells become brain, liver or malignant"
http://www.eurekalert.org/pub_releases/200...i-lds011209.php


B. From "Epigenetic Heredity Comprehension Advanced"
http://www.the-scientist.com/community/pos...0/122.page#1118

These above works are outstanding, yet could be more elaborative and revealing if gene-genome are realized to be the organisms they are.

One day, maybe yet in the 21st century, science will look back with amused disbelief at old terms and concepts like "letters of the DNA sequence" and "epigenetic information", in regards to genes-genome organisms...


Dov Henis

(Comments From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

Life's Manifest
http://www.the-scientist.com/community/pos...st/112.page#578

EVOLUTION Beyond Darwin 200


I.
At Darwin 200
Darwin Extended Beyond His Own Horizon
Rethought Unified Field Theory And Evolution

A. SN Special : Darwin turns 200
http://www.sciencenews.org/view/feature/id...arwin_turns_200
This special web edition of Science News includes expanded versions of articles from the magazine's print edition plus two additional features, all commemorating the 200th anniversary of the birth of Charles Darwin.

B. 22nd Century Conception Of Unified Field Theory And Evolution

The following brief essays present the 22nd century comprehension of evolution. They preserve Darwin's name in reference to Life Evolution in respect and appreciation of Darwin's promotion of the concept of evolution in life.

Life's Manifest
http://www.the-scientist.com/community/pos...st/112.page#578

Culture, A Ubiquitous Biological Entity
http://www.the-scientist.com/community/posts/list/98.page

Life And Darwinian Evolution, 21st Century Comprehension
http://www.the-scientist.com/community/posts/list/112.page

Rethink Unified Field Theory And Evolution
http://www.the-scientist.com/community/pos...60/122.page#982


II.
Evolution beyond Darwin 200

Per "Design And Randomness In Cosmic And Life Evolution"
http://blog.360.yahoo.com/blog-P81pQcU1dLB..._Q--?cq=1&p=404

Singularity and D-Infinity (max expansion, energy dilution) are the cosmic end states. Their in-between is a metastable state. This corresponds to commonsense observation: the denser the compacting goal of material the more energy is required, and vice versa the more thorough the disintegration of material the higher the amount of energy released. It seems that the cosmic universal process is E=Total[m(1+D)] , where D is the Distance from Big Bang point and the sum is of all spatial values of D from D=0 to D=selected value.

Presently the cosmos expands on the right side of the equation. However, within its accelerating overall energy dilution there are local phenomena of formation of temporarily constrained energy pockets that evolve backwords towards impansion. The two most obvious examples of such backword energy constraints are black holes and life, two distant relatives within a probably big family of various forms of cosmic 'backlash energy constraints'.


Suggesting,

Dov Henis

(Comments From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

A Probable Natural Paradigm To Surgery Checklist



A. "Checklist reduces surgery complications"
http://www.sciencenews.org/view/generic/id...y_complications
Measure twice, cut once: Going over a checklist of procedures in the operating room before and after surgery lowers the complication rate and, in developing countries, saves lives, a study in eight hospitals shows.


B. A Probable Natural Paradigm...

From "How Decisions Are Made Within The OCM (outer cell membrane)"
http://www.physforum.com/index.php?showtop...80&#entry325606

... the genome behaves not as being presided by a decider President Gene, but by innate complete credence to each and every member of the cooperative genome commune of its genes membership, thus accepting a priori the decision of the individual member, but But BUt BUT coupling this with a very elaborate system of crisscross checklisting of this decision by other members of the genome.

Dov Henis

(Comments From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1

Life's Manifest
http://www.the-scientist.com/community/pos...st/112.page#578

Wake up.
Re-think-plan-do-assess Sleep Melatonin works.

Sleep, Melatonin, Cancers And Beyond Darwin 200


I.

Darkness, melatonin may stall breast and prostate cancers
http://www.sciencenews.org/view/generic/id...ostate_cancers_
New studies suggest strong links between melatonin and breast and prostate cancers.

Melatonin is a hormone produced in the pea-size pineal gland in the center of the brain, secreted at night or in the dark. It is used to regulate the sleeping cycle and also found to correlate with other functions and problems in the body.


II.

Sleep and chirality are biological evolution evidence that genes are organisms

From "Circadian Rhythm-Metabolism Link Is Self-Explanatory"
http://www.physorg.com/news136122147.html

"Circadian rhythm-metabolism link discovered" ?
http://esciencenews.com/articles/2008/07/2...link.discovered

The findings also suggest that proper sleep and diet could help maintain or rebuild the CLOCK-SIRT1 equilibrium and may help explain why lack of proper rest or disruption in our normal sleep patterns is known to increase hunger, which can lead to obesity and related illnesses and can accelerate the aging process.


II.

Circadian-rhythm is the genes' innate rest time,

which - together with life's chirality - are the earliest evidences of Darwinian life evolution, the evolution of the primal, 1st stratum, Earth organisms, the genes.

From "SC displaced more easily when off-duty":

"It is unclear why the stem cells leave their niche during a patient's time of rest"
[Dov Henis comment posted in TS, 2008-10-10]
http://www.the-scientist.com/blog/display/55081/

SC are more easily displaced during the organism's rest time simply because their genes and genome are off-duty then, part of the duty is to be responsively on-call at the specific site where they are:

"Life's Chirality And Circadian Rhythm, Evidence Of Updated Darwinian Evolution"

A. Updated life's concepts:

http://www.the-scientist.com/community/pos...20/122.page#423

- Earth life consists of three strata: genes are primal organisms, genomes are evolved 2nd stratum organisms, and cellular organisms are evolved 3rd stratum.

- Life's evolution started at genesis.

- Life's evolution is not random. It is biased, driven by culture.


B. Earliest evidences of updated Darwinian evolution:

- Life's chirality
http://www.the-scientist.com/community/pos...st/122.page#387
http://www.physforum.com/index.php?showtop...80&#entry327715

- Circadian rhythm
http://forum.physorg.com/index.php?showtop...35&#entry301299


III.

Circadian Rhythm-Metabolism Link Is Self-Explanatory, and new "findings" are not required for suggesting that proper sleep and diet could help maintain or rebuild organism's "equilibrium" and for explaining why lack of proper rest, or disruption in our normal sleep patterns, is known to cause several unhealthy things in us and accelerate our aging process.


Suggesting,

Dov Henis
(Comments From The 22nd Century)
http://blog.360.yahoo.com/blog-P81pQcU1dLBbHgtjQjxG_Q--?cq=1