Life's Drive And Purpose, Choice Of Our Life's Purpose Is OURS

And this may be THE EXPLANATION of "uncertain replication" noted in the Harvard School of Public Health report:

http://www.physforum.com/index.php?showtop...80&#entry325606

My conjecture is that decisions by the genome are made based on an innate complete credence to each and every member of the cooperative genome commune of its genes membership, thus accepting a priori the decision of the individual member, but But BUt BUT coupling this with a very elaborate system of crisscross checklisting of this decision by other members of the genome.

Dov Henis

ReadAllAboutIt!
Production Rate and Output Discovered To Be Related!

A. The just discovered rhythm:

NYU dental professor discovers biological clock linking tooth growth to other metabolic processes

http://www.eurekalert.org/pub_releases/200...u-ndp040408.php

"In fact, the rhythm affects an organism’s overall pace of life, and its life span".


B. March 1990 published shell growth report:

http://www.springerlink.com/content/fu16128j79m783u4/

"Our results do not support the hypothesis of a general endogenous rhythm of microgrowth that closely corresponds to tidal rhythms in Cerastoderma edule. Instead, they emphasize the plasticity of deposition according to the origin and age of the experimental specimens."


C. And re the relationship between metabolism and life-span, of course many works have been reported since way back, and of course these are related to incremental growth...


Again and again and again, science must be rescued from its guilds, from its technicians and its politicians !


Dov Henis

'Science', 'guilds', 'technicians', 'politicians', are all people. It is therefore people who must be 'rescued' from themselves...again and again and again.



g.

The Drive and Purpose Of Life

Yes, ALL aspects of our culture are, of course, anthropo artifacts, including science. Yet among these artifacts science has a distinct uniqueness for us.

Repeating some observations noted earlier in this thread:

1. Uniqueness Of science among human artifacts:

During the recent several centuries in the course of human history science has been developed at an accelerating rate as a provider of convincing, ever closer approaching, approximate models of the real world.

2. The Cosmic Drive and Purpose Behind The Drive and Purpose Of Life:

The drive of life and of its evolution is to enhance the functionality and survivability of the genes, in order to maintain and enhance Earth's biosphere's temporary constrained energy storage, to maintain it BIO as long as possible. It is the genes that evolve, and the evolution of genomes and of 'higher strata' organisms is an interenhancing consequence of their genes' evolution.

The purpose of OUR life and its promotion is ours to choose and set. It derives solely from our cognition.


Dov Henis

It's not double trouble with insecticide-resistant mosquitoes
It's how decisions are made by the genome
It's genomorphic behaviour-expectation

A. Double trouble with insecticide-resistant mosquito

http://www.physorg.com/news126847671.html

The work compared survival rates (evolutionary fitness) of a strain of mosquito that carried two resistance genes, gene 'a' and gene 'k' for two different insecticides, to mosquitoes that only had gene 'a'. It turned out that the survival cost of having both genes was far lower than the cost of having just the gene 'a'.

One aspect of the results baffled the researchers. It was unexpected to them. "We know from evolutionary theory that mutations such as these are likely to be costly to their owners in environments where they have not been selected for”. In my (DH) words: when they are not 'born' into the genome but 'strangers' implanted into it.

B. How Decisions Are Made By The Genome

http://www.physforum.com/index.php?showtop...80&#entry325606

Who decides to do cell division or, generally, to do any thing, within the OCM, the outer cell membrane.

Let's leave aside the many decision-related questions such as when and how a need for a decision is prompted, how decisions are instructed and executed. Let's apply ourselves now ONLY to the question WHO makes the decision.

My conjecture is that the genome behaves not as being presided by a decider PG, by a President Gene, but by innate complete credence to each and every member of the cooperative genome commune of its genes membership, thus accepting a priori the decision of the individual member, but But BUt BUT coupling this with a very elaborate system of crisscross checklisting of this decision by other members of the genome.

C. Don't apply anthropomorphic thinking-expectations. Apply genomorphic behaviour expectation.

From genomorphic considerations Survival At ALL circumstances, both with and without insectiside, is best and should be selected. And in the genome cooperative community survival is best when there is cooperation-synergism between individual genes. There is little native genes-cooperation with a single stranger in the community and more cooperation when two different strangers are implanted in the community.

Profoundly, the overall consideration-cooperation of natives with implanted strangers display similarity between anthropo and geno behaviour patterns. Now, this should not be un-expected. This should be expected...


Dov Henis

Tomorrow's Comprehension Of Life And Darwinism


I. "Scientists find a fingerprint of evolution across the human genome"

http://www.physorg.com/news126893405.html

Unbelievable!
They are "finding a fingerprint of evolution across the human genome"!

What about the many hands with spread fingers of evolution across all genomes including the human genome? Don't they see them yet?

When I saw this report my immediate impulse was to counter it with a 'comment'. However, this impulse was followed with a feeling of exhausting exasperation at the obviosly blind-folded present scientists(?) groping their way in the fully lit genome. A plain short 'comment' would not begin to convince any reader, certainly not any indoctrinated science-guild member, that genes are interdependent organisms, members of a communal genome cooperative organism.

I therefore re-post here a collection of the main concepts posted earlier on this thread, hoping to convince some indoctrinated scientists to take a peep at life out of their blindfold, and to browse through some of the additional posts in this thread that elaborate on the subject with currently published research reports.


II. Tomorrow's Comprehension Of Life And Darwinism

Life, Tomorrow's Comprehension

Chapter I

Life, A Real Virtual Affair, Its Drive And Purpose

A. Life's Fractal Evolution

The observation of the CBF1 switch, from

http://www.physorg.com/news107357572.html

contributes to my view of the following major fractal chronological several-10^8-years macro layers of Life's evolution:

1 - Individual independent organisms, genes, evolve into cooperative interdependent genes aggregates, genomes.

2 - The outer cell's membrane (OCM) evolves as the first and major multi-functional organ of the
gene aggregates/genomes.

3 - Individual cells evolve into symbiotic systems.

4 - Evolution of multicellular organisms.

The biggest hindrance of scientific, and even technological, progress in comprehension and exploitation of Biology is the avoidance to accept-regard genes-genomes as organisms. And equally hindering is the lack of a term for genes-genome that explicitly and clearly defines them as organisms, as The Prime Cardinal Earth Life Organisms, distinguished from all cellular secondary stratum organisms.

This avoidance, which is fraught with implications about the nature of life, is also the biggest hindrance of human existential and social progress.

B. Viruses, Too, Are Bona Fide Organisms

Evolution is always in the direction of more effective survivability; however, this is not always in the direction of more complexing for coping with changing environments and competition. In a stable nutritious environment, like in Earth's oceans, coping with vital requirenments, evolution, is in the opposite direction, simplify tooling and means.

It is plain common sense that viruses, even Viroids and Virusoids, nothing more than single strands of DNA or RNA, sometimes only 200-300 nucleotides long, are organisms as alive as we are, evolved at life genesis era and selected for survival in forms, composition and capabilities by living, and even replicating, off their richer kin. Smart little buggers.

C. Evolution-Survival Rediscovered

Quoting from "Aging And Genetics" at

http://www.physorg.com/news107180970.html

"genes associated with longevity also became more common in each succeeding cohort. These results indicate that the frequency of deleterious genotypes may increase among people who live to extremely old ages because their protective genes allow these disease-related genes to accumulate,”

It appears that Evolution and Selection For Survival have just been re-discovered.

When when when will "scientists" and "science literature editors" get it through their scientific skulls that the source of our (and others species') individuals' uniqueness is the genome's polymorphisms, which come about from polymorphisms of its member genes.

It is about time that "scientists" make the Life Evolution mental leap, that they swallow and digest the revelation that a genome is a living complex organism consisting of (by now) interdependent symbiotic living member genes.

D. Cells Are Not The Base Organisms

It irritates me again and again when unscientific science editors allow reference to cells as organisms. Cells are the spaceships, the edifices, that house the genomes, THE organisms. Scientifically cells are NOT organisms. The outer cell membrane is an organ. Plain and simple.

A possible explanation of this scientific ignorance is our still incomplete knowledge of the nature of the constituents of the cells' contents and of the functions of the outer-cell-membrane , the multifunctional organ of the genome, coupled with misty comprehension of the nature of life.

Cellular membranes and cells' contents are evolution products of the in-cell organisms, the genomes. Continued reference to cells as organisms is a gross anachronism that brakes/slows developement of life sciences.

E. Drive and Purpose of Life

Cognition = the capability, process or act of thinking, questioning and analysing.

Cognition is Cultural, is Biological. Cognition derives from culture, which is a biological attribute of ALL organisms regardless of size or complexity.

Culture = the totality of ways of the organisms' dealing with (reaction to, manipulation of, exploitation of) its environment.

The choice and promotion of our purpose in life derives solely from our cognition.

F. Encyclopedia of Life (EOL)

I read some time ago that biologist E.O. Wilson has a new project, The Encyclopedia of Life (EOL), aiming to make all knowledge of the world's 1.8 million known species freely available online within just 10 years.

I suggest that this would be a waste of effort and of time, because it would most probably be based on the presently accepted tree of life, with one thing branching off after another, we f.e. listed under genus Homo species sapien, genus being a grouping of one or more related and morphologically similar species.

I suggest that in the age of Genetics and DNA identification and definitions of genes expressions phylogeny should be redefined and reorganized based on the evolution of the genetic material, as the tree of life should present comprehension of how the genetic material has been evolving on Earth since four billion yrs ago...

The differences between the trees of life based on the classical "descriptive" taxonomy or on genetics would be great and of great consequences. A genetic-based tree would not only correct several wrong "placings" and throw light on and bring to view yet undiscovered junctions-relationships of genera, but I posit that - most important - the comprehension that ALL LIFE EVOLUTION is the evolution of genes/genes-associations since four billion yrs ago, I posit that this comprehension might have a radical influence on the cognition and culture of humans and on their implications in personal and societal life organizations.

G. More Re Life's Drive and Purpose

1. If one accepts, intuitively and logically, Pasteur's observation that all life must come from previously existing life, then the answer to "what makes a mono- and poly-cell life-form a Life" is the answer to "what makes some molecular associations in cells LIVES", and vice versa. It is the "lifehood" of genes that makes us and all other forms of life on Earth living organisms, and evolution has been the route of Life's ever more complexing progress since the first replication of the first gene.

Early independent peptides, primordial genes, have entered into symbiotic associations in which eventually each of the ever increasing host of functions/tasks vital for the evolving associations is taken up by the member most efficient at it, leading to gene speciation and to gene specialization.

The history of life begins with independent genes, cascading fractally from single independent genes to agregate of genes, then to agregate of agregate of genes. Cooperative association is an inherent feature of life throughout all its evolution and at all its levels, in pre-cell and in mono-cell life and in mono-cell communities and in poly-cell life-forms and in communities of poly-cell life forms.

2. The totality of life in Earth's biosphere (the outermost part of the planet's shell — including air, land, surface rocks and water — within which life occurs, and which biotic processes in turn alter or transform. Wikipedia.) is a temporary grand store of energy, and all living organisms are elaborate temporary energy storage containers and all base genetic materials are "Life quanta", carriers of "Life photons". Humans are just one of the many types of Earth's living organisms, regardless of the reason and purpose of their self-inflated high-self-esteem.

3. Life's evolution has been and still is and will continue to be the evolution of genes. The total number of defined genes, each with its own unique identity/functional-capability is, of course, the number of organisms' species multiplied by their number of different genes, which are now dependent-symbiotic members in chromosomes, cooperative-communes of genes. It is the GENES that evolve, and the evolution of the chromosomes and of 'higher strata' organisms is simply a consequence of their genes' evolution. The drive and purpose of evolution of the organisms is to enhance the functionality and survivability of the genes, in order to maintain and enhance Earth's biosphere energy storage, to maintain it BIO.

4. This is the plain bare story of the drive and purpose of life. We do not yet comprehend what ENERGY is generically. We are just beginning to comprehend the nature of the raw material called Life and that the purpose of OUR life is ours to choose and develop and follow.

Again, humans, like every other organism, are just products of evolution of the individual and collective genes of their genome. And humans, like every other organism, repay their genetic formers with feedbacks that serve to further modify their forming genes and to increase their formers' survivability. The 'higher-strata' organisms are only means of survival of THE PURPOSE of life, which is their base genes-genome. However, as far as the 'higher stratum' organism is concerned it itself IS the purpose of life; ask any human...

H. Earth Life Is A Real Virtual Affair

Earth Life Is A Real Virtual Affair; it pops in and out of existence in its matrix, which is the energy constrained in Earth's biosphere .

I. Tree of Life

1. In Biology Online, 26-28 Nov 2006, AG asks:

How is the Tree of Life rooted?... What could the last universal common ancestor be?

Dov suggests

http://blog.360.yahoo.com/blog-P81pQcU1dLB..._Q--?cq=1&p=194

2. Scientism and "evolutionary thinking" suggest that the study of the nature of life must be focused on the nature of the presently known earliest genes and on the probable nature of their probable earlier editions, backwards to the treshold of formation-transition of pre-RNA molecules into their self-replicating RNA editions, in the company of their precursors and of the predecessors of the precursors.

3. Most probable conjecture of the constellation of the Stealthy Life Genesis:

(a) In a (need composition definition) aqueous medium are present all components of the early "replicating configurations" plus all the predecessors of those components, and

(b) the energy balance of each of the progressing (steps) reactions, along the direction from the base elements level up to the replicator, are always forward-favoured, so that in the presence of all the required elements the replicator's formation energetically draws the progressive reactions.

The starting clues are, of course, the earliest available replicating compositions and their in-cell processes, and the starting unknown variables are the systems' base molecules and the systems' energetic circumstances.

© The essential early events of the energy-contents-driven "chemicals-to-life" progression comprise single-strand base extensions and ligations. DNA formation occurs most probably very much later.

All the consecutive steps in the progression are energy-contents-driven. Thus the chemicals-to-life transit is not a single dramatic step/rung of the ladder but consists of multi-small-steps/rungs and, due to variations in circumstances and in-line with the fractal nature of everything in the environments, it is random/stochastic.

(d) I conjecture life's genesis much earlier than the celling of genes. Genomes are communal coops of what way back originally were RNA independent genes, these various/different genes being then the first proliferrable life forms. Evolution and survival directed them and their much younger DNA progeny to become united, chromosomes and genomes, simply because cooperation is the most survivable mode, and the further process of evolution included celling for control of environmental parameters plus ever increasing member genes specialization as more capabilities evolve by some individual members of the commune of genes.

4. AG : I was also leaning toward Woese's theory.

Dov : Genesis Of Life

Carl Woese ( June 9, 1998 ):

"The ancestor ( of life ) cannot have been a particular organism, a single organismal lineage. It was communal (13, 22), a loosely knit, diverse conglomeration of primitive cells that evolved as a unit, and it eventually developed to a stage where it broke into several distinct communities, which in their turn become the three primary lines of descent".

Dov Henis:

Earth life's genesis cannot have been cell(s). Cells, liken all (every) objects and processes and natural laws in the universe, are - since singularity - products of evolution and are continuously further evolving. Everything in the cosmos is fractal, rehappens on many scales, and is continuously evolving. Each and every system in the universe continuously evolves within the total universal evolution and all the systems' evolutions are intertwined. Thus the root of earth's life cannot have been deus-ex-machina cells. Cells cannot have been but one of the forms of products of evolution of energy-transformation-storage systems, since at the beginning was the energy singularity, at the end will be near zero mass and an infinite dispersion of the beginning energy, and in-between, the universe undergoes continuous evolution consisting of myriad energy-to-energy and energy-to-mass-to-energy transformations. Therefore the roots of earth-life's genesis must have been much earlier than the celling of genes, in cosmic phenomena of active temporary reservoirs or pockets or bubbles of energy, on Earth in formation of individual RNA replicating genes.

end chapter I

----------------------------------

Chapter II

Natural Selection Is A Two Level Interdependent Affair

1) Evolution ensues from genome/genes modifications ("mutations"), inherently ever more of them as new functional options arise for the organism.

2) Modifications of genome's functional capabilities can be explained by the second-stratum organism's culture-life-experience feedbacks to its genome, its prime/base organism. The route-modification selection of a replicating gene, when it is at its alternative-splicing-steps junctions, is biased by the feedback gained by the genome, the parent organism, from the culture-life-experience of its progeny big organism. THIS IS HOW EVOLUTION COMES ABOUT.

3) The challenge now is to figure out the detailed seperate steps involved in introducing and impressing the big organism's experiences (culture) feedbacks on its founding parents' genome's genes, followed by the detailed seperate steps involved in biasing-directing the genes to prefer-select the biased-favored splicing.

4) I find it astonishing that only very few persons, non-professional as well as professional biologists-evolutionists, have the clear conception that selection for survival occurs on two interdependent levels - (a) during the life of the second-stratum progeny organism in its environment, and (b) during the life of its genome, which is also an organism. Most, if not all, persons think - incorrectly - that evolution is about randomly occurring genes-genome modifications ("mutations") followed with selection by survival of the progeny organism in its environment. Whereas actually evolution is the interdependent , interactive and interenhencing selection at both the two above levels.

end chapter II

---------------------------------

Chapter III

The Cosmic Drive and Purpose
Behind
The Drive and Purpose Of Life

(1) Again, Earth Life Is A Real Virtual Affair; it pops in and out of existence from its matrix, which is the energy constrained in Earth's biosphere. The totality of life in Earth's biosphere (the outermost part of the planet's shell, including air, land, surface rocks and water, within which life occurs, and which biotic processes in turn alter or transform. Wikipedia.) is a temporary grand store of constrained energy, and all living organisms are elaborate temporary energy storage containers and all base genetic materials are "Life quanta", carriers of "Life photons".

(2) Singularity and D-Infinity (max expansion/ cosmic energy dilution) are the two cosmic stable states. Their in-between is a metastable state, which is an everyday commonsense observation, like the observation that the denser the compacting goal of material the more energy is required, and vice versa the more thorough the disintegration of material the higher the amount of energy released. It seems that E=mC^2 is a specific case of the cosmic (and universal) process

E=Total[m(1+D)]

where D is the Distance from Big Bang point and the sum is of all spatial values of D from D=0 to D=selected value.

[BTW, (Nov 9 2006), following Newton (1) gravity is decreased when mass is decreased and (2) acceleration of a body is given by dividing the force acting upon it by its mass. By plain common sense the combination of those two 'laws' may explain the accelerating cosmic expansion of galaxy clusters, based on the above E/ m/ D suggested relationship.]

(3) Since the Universe, including its sub-systems, also Life, is a continuously evolving fractal system, ergo energy is the base element of everything and individual genes are the base elements of Life. Cosmic evolution is evolution of energy, and within it Life's evolution is the evolution of the genes/energy-quanta carriers.

At the beginning was the energy singularity. At the end will be near zero mass and an infinite dispersion of the beginning energy. In-between, the universe undergoes continuous evolution, consisting of myriad energy-to-energy and energy-to-mass-to-energy transformations. The cosmos evolution process comprises, though, phenomena of forms of temporary energy storage pockets, energy dispersion constraints. Examples of such temporary pockets are black holes of all sizes, and all forms of biospheres if/wherever they are.

The temporary constrained energy pockets are far-removed versions, up-fractionally evolved, scattered cosmic fragmants of singularity-akin energy sources. Energy stored in the temporary constrained energy pockets resists dispersion; we do not yet comprehend why and how. However, we comprehend that we, all Earth life, are real virtual products formed by Earth's biosphere energy for maintaining Earth's biosphere bio as long as possible.

end chapter III

-------------------------------------

Chapter IV

Science-Informed "Theism" (SIT), And Religion

There is no more competition between science and faith than between science and arts or science and tourism.

Science is systematized knowledge, whereas faith, arts and tourism and a host of other matters are components of culture, where culture is a ubiquitous biological entity of ALL organisms regardless of size or complexity, selected for survival as the sum total of reactions to and exploitations by the genome of the out-of-cell environments, sensed by the OCM, outer-cell-membrane of the genome, where this OCM is simply and plainly a multi-purpose organ of the in-cell resident communal organism, the genome.

(1) Science's "theism"

- Science's "theism" is An (therefore not The) unknowable undefined source of the energy that constitutes the unknowable undefined Universe.

- The unknowability of the source of cosmic energy, which is also life's matrix, leaves the choice and promotion of our purpose in life to be derived solely from our cognition.

- A term needs to be drawn for a concept and practice of deriving humanity's purpose and course of life. The term should not be related to theism or religion because SIT is NOT founded on faith-belief, and SIT's ethics code is founded on rational commitment and dedication to Life's inherent characteristic, which is cooperation for survival.

(2) Religion, Scientifically

A. Religion, A Human Evolution Definition

From a posting of mine in an evolution discussion forum, written and meant with complete respectful sincerity, at

http://forum.physorg.com/index.php?showtop...=0&#entry286766

"A religion is a human artifact for survival of a specific human cultural phenotype, comprising cultural tool-kit and technique ascribed by its adherents to be of higher esteem and benefit than other human cultural survival plans".

B. Sincerely thinking so

Wondering if religious persons who also "accept" science would accept this definition, even with steady unwavering respect and commitment to their religion. IMO such acceptance would contribute respect to religion and to religious persons.

C. Major Conceptual Hierarchies:

- Religion is a progeny of culture, culture being a biological entity, like

- Technology is a progeny of science, like

- Biology is a progeny of life's evolution, like

- Universal Evolution is a progeny of Energy.

D. Uniqueness Of Science Among Human Artifacts

During the recent several centuries in the course of human history Science has been evolving at an accelerating rate as a provider of convincing, ever closer approaching, approximate models of the real world.

We understand that Science is just one of the components of our Culture, our package of capabilities to observe the environment, react to it and exploit it for our satisfaction and survival.

Yet there is a distinct, even if still small, growing spreading tendency to accept the findings of evolving Science with ever increasing respect and appreciation, especially in the realms of all forms and types of technology and of life disciplines.

The crucial 21st century question facing humanity is how much further and into which additional disciplines may or should Science be welcome and adopted by society at large, with what hopes and with what expectations.

end chapter IV

and respectfully resting my case,

Dov Henis

----------------------------------------------------------

PS:

I also suggest that general comprehension of evolutionary biology is an essential pre-requisite to the study of cultural anthropology.

- Culture is a basic biological entity. It is a ubiquitous elaboration/extension of genome's activity beyond its outermost cell membrane and of multicelled organisms' behaviour. It has been selected for survival of the genome as means of extending its exploitation capabilities of the out-of-cell circumstances, consequent to the earlier evolution and selection of the genome's organ, its outermost cell membrane, for controlling the inside-of-cell genes'-commune environmental circumstances.

- Every cultural element is an artifact which involves biological intra-/inter-cell expression and/or process; biological and cultural domains are not ontologically distinct, but instead culture inheres in biology.

- In the case of human cultures, ethnocentrisms are phenotypic cases of anthropocentrism; biologically both are normal Darwinian biological survival phenomena. Thus ethnocultures are human phenotypic survival tools.

DH

********************************************************************

Darwinism Corrected To Tomorrow's Comprehension.

Darwinians, It Is Culture That Drives Evolution!

March 16 2008

http://www.physforum.com/index.php?showtop...65&#entry323376

"By plain common sense it is therefore culture, the ubiqitous biological entity, that drives earth life evolution."

March 1 2008

"Culture Is Biology, It Imprints Genetics"

http://forum.physorg.com/index.php?showtop...65&#entry316631

I. Quotes from "Chimp and human communication trace to same brain region"

http://www.eurekalert.org/pub_releases/200...p-cah022108.php

" An area of the brain involved in the planning and production of spoken and signed language in humans plays a similar role in chimpanzee communication.

This might be interpreted in one of two ways:

One interpretation of our results is that chimpanzees have, in essence, a ‘language-ready brain'. By this, we are suggesting that apes are born with and use the brain areas identified here when producing signals that are part of their communicative repertoire.

Alternatively, one might argue that, because our apes were captive-born and producing communicative signals not seen often in the wild, the specific learning and use of these signals ‘induced’ the pattern of brain activation we saw. This would suggest that there is tremendous plasticity in the chimpanzee brain, as there is in the human brain, and that the development of certain kinds of communicative signals might directly influence the structure and function of the brain."

II. Quotes from earlier postings in this thread:

Culture Is Biology, It Affects Genetics

The Common Mistake: Genetic Changes Have NOT Made Us Human; Human Culture Has Been Changing Our Genetics.

A. http://www.eurekalert.org/pub_releases/200...u-ahe120607.php

Are humans evolving faster?

Findings suggest we are becoming more different, not alike.

B. http://www.eurekalert.org/pub_releases/200...w-gsp120507.php

Genome study places modern humans in the evolutionary fast lane.

C. http://blog.360.yahoo.com/blog-P81pQcU1dLB..._Q--?cq=1&p=207

From my postings way back in 2005, which cites genetic evidence/demonstration of the workings of human cultural evolution:

- From Science, 2 Sept 2005: "Page's team compared human and chimp Ys to see whether either lineage has lost functional genes since they split.

The researchers found that the chimp had indeed suffered the slings and arrows of evolutionary fortune. Of the 16 functional genes in this part of the human Y, chimps had lost the function of five due to mutations. In contrast, humans had all 11 functional genes also seen on the chimp Y. "The human Y chromosome hasn't lost a gene in 6 million years," says Page. "It seems like the demise of the hypothesis of the demise of the Y," says geneticist Andrew Clark of Cornell University in Ithaca, New York.

Chimp's genome has been continuing survival by physiologically adapting to changing environments.

- But look at this: From Science, Vol 309, 16 Sept 2005, Evolving Sequence and Expression:"An analysis of the evolution of both gene sequences and expression patterns in humans and chimpanzees...shows that...surprisingly, genes expressed in the brain have changed more on the human lineage than on the chimpanzee lineage, not only in terms of gene expression but also in terms of amino acid sequences".

Surprisingly...???

Human's genome continued survival mainly by modifying-controling its environment.

- And I suggest that detailed study of other creatures that, like humans, underwent radical change of living circumstances, for example ocean-dwelling mammals, might bring to light unique effects of culture-evolution processes and features of evolutionary implications parallel to those of humans.

D. Chapter II, Life, Tomorrow's Comprehension:

http://blog.360.yahoo.com/blog-P81pQcU1dLB..._Q--?cq=1&p=372

Natural Selection Is A Two Level Interdependent Affair

1) Evolution ensues from genome/genes modifications ("mutations"), inherently ever more of them as new functional options arise for the organism.

2) Modifications of genome's functional capabilities can be explained by the second-stratum organism's culture-life-experience feedbacks to its genome, its prime/base organism. The route-modification selection of a replicating gene, when it is at its alternative-splicing-steps junctions, is biased by the feedback gained by the genome, the parent organism, from the culture-life-experience of its progeny big organism. THIS IS HOW EVOLUTION COMES ABOUT.

3) The challenge now is to figure out the detailed seperate steps involved in introducing and impressing the big organism's experiences (culture) feedbacks on its founding parents' genome's genes, followed by the detailed seperate steps involved in biasing-directing the genes to prefer-select the biased-favored splicing.

4) I find it astonishing that only very few persons, non-professional as well as professional biologists-evolutionists, have the clear conception that selection for survival occurs on two interdependent levels - (a) during the life of the second-stratum progeny organism in its environment, and (b) during the life of its genome, which is also an organism. Most, if not all, persons think - incorrectly - that evolution is about randomly occurring genes-genome modifications ("mutations") followed with selection by survival of the progeny organism in its environment. Whereas actually evolution is the interdependent , interactive and interenhencing selection at both the two above levels.

E. Eventually

Eventually it will be comprehended that things don't just "happen", "mutate", randomly in the base-prime organism, genome, constitution; the capability of the base-prime organisms to "happen" and "mutate" is indeed innate, but things "happen" and "mutate" not randomly but in biased directions, affected by the culture-experience feedback of the second level multi-cell organisms (or the mono-cell communities).

Dov Henis

Cells on path to becoming mature T-cells


A. "Cells on path to becoming mature T-cells more flexible than commonly thought"

http://www.physorg.com/news126976798.html


B. "Commonly thought" happens to have been of general applicability and with great insight

http://blog.360.yahoo.com/blog-P81pQcU1dLB..._Q--?cq=1&p=149

From: Science, Vol 308, Issue 5728, 1563-1565 , 10 June 2005, Immunology: "Opposites Attract in Differentiating T Cells, Mark Bix, Sunhwa Kim,Anjana Rao.

"During differentiation, precursor cells with progressively narrowed potential give rise to progeny cells that adopt one of two (or more) divergent cell fates. This choice is influenced by intricate regulatory networks acting at multiple levels (1). Early in differentiation, precursor cells show low-level activation of all progeny genetic programs. Bias toward a given lineage comes from environmental inputs that activate powerful positive- and negative- feedback loops, which work in concert to impose selective gene expression patterns".


Dov Henis

Genetics, Epigenetics And ET Alien Scientists


A. I find this abstract ironically amusing

http://www.eurekalert.org/pub_releases/200...f-ctu041008.php

"...unravel how genes are regulated and shed light on how cells become different..."

"...biology’s most challenging goals, understanding how epigenetic marks contribute to regulation of gene expression..."


B. A good explanation of epigenetics, and dictionary definitions

http://jama.ama-assn.org/cgi/content/full/299/11/1345

epi·gen·e·sis: 1: development of a plant or animal from an egg or spore through a series of processes in which unorganized cell masses differentiate into organs and organ systems; also : the theory that plant and animal development proceeds in this way —

epi·ge·net·ic: 1 a: of, relating to, or produced by the chain of developmental processes in epigenesis that lead from genotype to phenotype after the initial action of the genes b: relating to, being, or involving changes in gene function that do not involve changes in DNA sequence


C. The ET Alien team's report

I'm reminded of the story about the report of the first ET alien team who circled Earth and observed the goings-on on its surface. They reported home that the main Earth organisms are various forms of mobile on-round-organs configurations, often containing small in-and-out-going parasites.


D. Cells are not organisms

The outer cell membranes (OCM) are organs. The compositions, structures, shapes and functional capabilities of these organs are very elaborate, but they are still organs, not organisms. The organisms, their "parasites", are the genomes that design and construct the OCMs and utilize them.


E. The universe and life are fractal

Everything in the universe, including life, is fractal and evolves fractally. Earth life started with not-yet-genomed nor-celled genes. Its earliest edition of genomed-celled construction were the Archaea (archae=ancient, primitive). Had the pre-Archaea genes become "parasites" in their OCM? The OCM became necessary for its designers-inhabitants for surviving changes in their circumstances.

Sometime in the future humanity may have to, fractally, repeat the feat of the archaea...to learn to survive in hostile circumstances in enclosures. Would'nt it be ironically amusing?...

For the rational common-sense progress of human culture humanity would be better off to free itself from old conceptions-traditions and further promote its scientific cognition.

Dov Henis

New Discovery!
Gene-environment interaction in yeast gene expression!

http://www.physorg.com/news127369366.html

Unbelievable!

Unexpected!

Culture Is Biology, It Imprints Genetics, Drives Evolution!...

It Is Culture That Drives Evolution!...

Gee! Some scientists are beginning to get a glimpse into life beyond the pre- Copernicus/Gallileo conceptions...


Dov Henis

Teleology Is Universal

A. Again, the probable reason for life's amino acids chirality:

Darwinian evolution started at life's day one, with the genesis of the first organisms, the replicating oligomers, the pre-archaea genes. It started under yet-unknown energetic conditions, by a serendipitous occurrence, with oligomeric (RNA?) conformations, in a soup containing all their essential molecular progenitors. These conformations happened to maintain balance of energy in the direction of their polymerization to lengths precipitated out of their soup as determined by the nature and conditions of the soup.

The sugars and the nitrogen-based compounds that, together with the phosphates, are the components of genes, of life's organisms, are chiral. There probably is an energetic advantage in homochirality and chiral homogeneity for the self-replication of these biopolymers.

This serendipitous occurrence set up a matrix-field of energy with a potential extended between its source, on-Earth incoming energy, and the precipitating organisms, the genes. This was the genesis of the ongoing formation and maintenance of Earth's biosphere.

And since the biosphere had thus started it could only evolve in the directions of more favorable energy balances-packages and towards stabler energy-packages conformations. Survival was the direction. Earth's biosphere had embarked on the course of its evolution.


B. Some definitions, with "end" replacing dictionary's 'cause' or 'design' or 'purpose'

- tele-, telos end

- teleology = a doctrine explaining phenomena by final end; the fact or character attributed to nature or natural processes of being directed toward a specific end; the referral to the end of universe as an explanation of natural phenomena.

teleonomy = the quality of survival of structure or function in living organisms due to evolutionary adaptation.


C. Teleology exist in all nature's systems, both living and nonliving. It is universal.

Since the Universe (including its sub-systems, also Life) is a continuously evolving fractal system, ergo energy is the base element of everything. Cosmic evolution is evolution of energy. At the beginning of the present cosmic cycle was the energy singularity. At its end there will be a small amount of mass and an infinite dispersion of the beginning energy. In-between, the universe undergoes continuous evolution, consisting of myriad energy-to-energy and energy-to-mass-to-energy transformations.

Evolution ensues from and consists of systems' modifications ("mutations"), inherently ever more of them as more new options arise for the systems, be they non-living or living.

Life systems are temporary packages of energy. On Earth they are components of the grand, temporarily constrained, biosphere energy store. Their 'end' is to enhence and maintain their matrix, the biosphere, bio.

In life systems modifications of genome's functional capabilities can be explained by the second-stratum organism's ubiquitous culture-life-experience feedbacks to its genome, its prime/base organism. The route-modification selection of a replicating gene, when it is at its alternative-splicing-steps junctions, is biased by the feedback gained by the genome, the parent organism, from the culture-life-experience of its progeny organisms. THIS IS HOW LIFE EVOLUTION COMES ABOUT.

For non-life systems there is no mediating culture. The interaction between environments and systems are direct, in the direction towards the 'end' of the present phase of the universe.


Suggesting,

Dov Henis

Inanimate And Animate Differ Essentially In Constrained Energy State
There Is No Chemical Demarcation Line Between The Non-Living And Living


A. From: Are Living Organisms "Genetic Blue Prints"?
Dec 31 2007
http://www.physforum.com/index.php?showtop...35&#entry296678

"I suggest again and again ad absurdum what should be clear to every human with plain common sense, that "This Means" that living organisms are not “Genetic Blueprints Into Molecular Building Blocks". You and I do not become any more "genetic blue prints" when we carry out any process or operation, than our genes-genomes thus become "genetic blue prints" when they carry out any process or operation...
With best new year greetings to all our genetic blue prints forum members,..."


B. There is no chemical demarcation line between the non-living and living

It should be stated clearly, though, that not only genes-genomes as well as mono- and multi- cellular organisms are all similarly animate, but also that there is no chemical demarcation line between the non-living and living.

The Inanimate And Animate Differ Essentially In Their Constrained Energy State.


Suggesting,

Dov Henis

HenisDov the source and purpose of any creation is from the creator not the created. Man is seen to create and is able to do so on a daily basis. We see all changes of natural order coming from the design of man. Design and order only come from creation and the fact that design and order existed before man should tell you something.

All changes except for those caused by man follow natural order of the basic creation. There is no act of new creation in any evolutionary process. Evolution follows predetermined laws.

Earthlings you have no control of LIFE's drive or purpose

You are but pawns in a greater entity
that really does not "care" what happens to you.

It must win and earthlings will be used for that purpose.

Sons Of Darkness Versus Forces Of Light

A. Enlightenment = a philosophic movement of the 18th century marked by a rejection of traditional social, religious, and political ideas and an emphasis on rationalism.

B. As soon as a son of darkness spots even a faint ray of enlightenment stealing in through a minute craze in the enclosing walls he hurries to plug the craze lest it creeps in...

Dov Henis

I Am Stumped By The Researchers Stumped By Drug Addiction Scene

A. From http://www.physorg.com/news127559887.html

"...it’s ironic that humans and other mammals don’t merely tolerate the toxins, but can crave them and even develop dependencies on them."

B. From http://www.physforum.com/index.php?showtop...95&#entry331389

"Don't apply anthropomorphic thinking-expectations. Apply genomorphic behaviour expectation.

From genomorphic considerations Survival At ALL circumstances, both with and without insectiside, is best and should be selected. And in the genome cooperative community survival is best when there is cooperation-synergism between individual genes. There is little native genes-cooperation with a single stranger in the community and more cooperation when two different strangers are implanted in the community."

C. Remeber, two interdependent organisms are involved in drug addiction

Where is the irony?

Likewise in this case, from the genomorphic considerations of the plant producing the toxin the more toxin seekers-cravers the more enhanced its own survivability.

Whereas in regards to the seekers-cravers, obviously since they do not feed back a rejection-damage to their genome, their base prime organism, why should their genome select an uncalled-for "defense modification-mutation"?.

(If/when our genome eventually selects a specific toxin defense gene it will take, as nature goes, many more years...)

Dov Henis