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> Life's Drive And Purpose, Choice Of Our Life's Purpose Is OURS
HenisDov
Posted: Mar 19 2008, 04:21 PM


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QUOTE (Capracus @ Mar 19 2008, 01:20 PM)
HenisDov, I think it would be more accurate to say that culture is one of the many driving forces of evolution.



I'm curious.

If you have followed this thread since some way back you'll notice that I have been citing scientific evidence for my statement. I also presented rational science-informed reasons for my statement.

I wonder what scientific evidence or rational reasons you have for your statement.

Respectfully,

DH

This post has been edited by HenisDov on Mar 19 2008, 04:24 PM
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HenisDov
Posted: Mar 20 2008, 05:48 AM


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Monocells Community And Multicelled Organism Profiled Genetically Alike,
Both Are Doing Best To Survive.



The very interesting rational approach is presented at

http://www.nsf.gov/news/news_summ.jsp?cntn...g=NSF&from=news

The report includes also this interesting info:

Nowhere is the principle of "strength in numbers" more apparent than in the collective power of microbes: despite their simplicity, these one-cell organisms, that number about 5 million trillion trillion strong (no, that is not a typo) (5x10^30 by the American system. Dov) on Earth, affect virtually every ecological process, from the decay of organic material to the production of oxygen... and viruses are known to be ten times more abundant than even microbes...

Fwd by Dov Henis
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HenisDov
Posted: Mar 21 2008, 06:52 AM


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Yeast, worms and people may age by similar mechanisms...

Because The Organisms Genes Experience Aging Too...


A. Yeast, worms and people may age by similar mechanisms...
http://www.eurekalert.org/pub_releases/200...l-got030608.php

"Nearly all organisms experience aging".


B. And The Organisms Genes Do Not Experience Aging

Right you are. "Nearly all organisms experience aging". But why "nearly"?

Not only yeast, worms and people but also genes and the interdependent-genes-communes, genomes. These are organisms, too. It is their "lifehood" that makes you and all life forms "alive".

By plain common sense, my favorite scientific approach, they should also be "experiencing aging"

C. It is the aging of genes that makes all organisms age

Since genomes are cooperative communes of interdependent genes there are many genes that "modulate aging" to smaller or larger extent at smaller or larger time-rate depending on circumstances and environment and.... Various things effect them and impair their functionalities and ....

Suggesting,

Dov Henis
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HenisDov
Posted: Mar 21 2008, 10:13 AM


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QUOTE (HenisDov @ Mar 21 2008, 06:52 AM)
Yeast, worms and people may age by similar mechanisms...

Because The Organisms Genes  Experience Aging Too...


A. Yeast, worms and people may age by similar mechanisms...
http://www.eurekalert.org/pub_releases/200...l-got030608.php

"Nearly all organisms experience aging".


B. And The Organisms Genes Do Not Experience Aging ?

Right you are. "Nearly all organisms experience aging". But why "nearly"?

Not only yeast, worms and people but also genes and the interdependent-genes-communes, genomes. These are organisms, too.  It is their "lifehood" that makes you and all life forms "alive".

By plain common sense, my favorite scientific approach, they should also be "experiencing aging"

C. It is the aging of genes that makes all organisms age

Since genomes are cooperative communes of interdependent genes there are many genes that "modulate aging" to smaller or larger extent at smaller or larger time-rate depending on circumstances and environment and.... Various things happen to them or affect them and impair their functionalities and ....

Suggesting,

Dov Henis


This line in the quoted posting should have ended with a question mark, thus:

B. And The Organisms Genes Do Not Experience Aging ?

apologizing for having missed it...

Dov Henis

This post has been edited by HenisDov on Mar 21 2008, 10:27 AM
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HenisDov
Posted: Mar 23 2008, 05:18 PM


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Evolution Does Not "Tend To Do" anything

Insights From Genes Unique To Humans

http://www.eurekalert.org/pub_releases/200...o-fsh032108.php

Each and every properly conducted research project adds information and data to the store of our knowledge, regardless of the rational of the plan of the research or of the conclusions attributed to its results, this work not excepted.

Yet, brief remarks re some of the statements in its above abstract report:

1) "Evolution, Stahl notes, naturally tends to retain genes involved in the most important components of metabolism".
Evolution does not "tend do do" anything. Evolution doe not have an active ubiquituous existence anywhere and it is NOT A LAW OF NATURE. Evolution is plainly and simply one of a variety of systemized observations-reports of processes and events. In genetics evolution is driven by the culture of the second strata organisms or by the culture of monocellular communities and is executed by their prime stratum organisms, their genome's genes.

2) Are "humans-only genes" and "hominoids genes" interchangeable terms?

I wonder...

3) "...interesting for evolutionary biologists to try to develop a sense for where these humans-only genes come from," Stahl says. "The building blocks of these genes may be present but not active in earlier species."

I.e. someone, sometime back, somehow, installed those "building blocks", those just-right-dedicated Lego pieces, and fixed them to be dormant until sometime somehow brought their collection to life, to assume specific function(s)...to become active genes...

Again, science must be rescued from the middle ages !

suggesting,

Dov Henis
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HenisDov
Posted: Mar 24 2008, 09:28 AM


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How Decisions Are Made Within The OCM (outer cell membrane)


A. From "Bistable Cell Division Switch":

http://www.eurekalert.org/pub_releases/200...c-ast032108.php

This switch is part of a critical pathway that controls cell division, production of new cells. Before a cell starts to divide, it goes through a checklist to make sure everything is in order. If the checklist uncovers something wrong, it can halt the process. But once a cell passes a "restriction point", there’s no turning back, no matter the consequences. The switch controls this milestone and is key to cell growth.

The switch is part of the Rb-E2F signaling pathway. Rb, or retinoblastoma, is a key tumor suppressor GENE, and E2F is a protein, a GENE TRANSCRIPTION FACTOR that governs the expression of all the genes essential for cells to grow. This wiring diagram is fundamentally the same in different organisms, to regulate their growth.

The cellular pathway that includes the switch is found in all multi-cellular life, from plants to people. A cell decides to trigger the pathway when it receives an external chemical signal to grow.


B. Who decides to do cell division or, generally, to do any thing, within the OCM, the outer cell membrane.

Let's leave aside the many decision-related questions such as when and how a need for a decision is prompted, how decisions are instructed and executed. Let's apply ourselves now ONLY to the question WHO makes the decision.

My conjecture is that the genome behaves not as being presided by a decider PG, by a President Gene, but by innate complete credence to each and every member of the cooperative genome commune of its genes membership, thus accepting a priori the decision of the individual member, but But BUt BUT coupling this with a very elaborate system of crisscross checklisting of this decision by other members of the genome.


Conjecturing,

Dov Henis
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HenisDov
Posted: Mar 25 2008, 04:25 PM


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Science Must Refresh Concept Of Evolution

A. Unique Human Brain Language Feature Sheds Light On Human Language Evolution

http://www.physorg.com/news125500956.html

"DTI now makes it possible to understand how evolution changed the wiring of the human brain to enable us to think, act and speak like humans."


B. Come On, Science Technicians, Rethink, Refresh Concepts!

It is NOT that the Uniquely Human Brain Wiring ENABLED US to think, act and speak like humans.

It is that our innitiation and application of thinking and speaking lead to the expansion and modification, by our genome, of the uniquely human brain wiring, that enabled further development of these survival capabilities!

This difference in comprehension is not a minor difference. It is a major prime difference in the conception and understanding of what evolution is and how we fit in it!


Dov Henis
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HenisDov
Posted: Mar 29 2008, 05:25 AM


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Comprehension Of Evolution

This is not another attempt to DEFINE evolution.

This is an attempt to COMPREHEND evolution. An attempt to comprehend evolution with, again, my favorite scientific approach, with common sense.

Common sense leads me to start my this attempt with the presently conjectured start-state of the evolution of all evolutions, with singularity, and to then ask what is next. Should we now seek Evolution's Potential? Do we next need a conjectured end-state?

Is evolution a process that arrives at an end-state? How will cosmic expansion end?

We cannot even conjecture...

Will it end with a stable steady state, a balance between the ever self-diluting force that accelerates the motion of galaxies clusters and the since-singularity tensioned space-distance cosmos matrix? Or will it end with a collapse, with a return impansion towards singularity, that will then again ...?

And how may it evolve towards its end state?...

Is this unknowability what constitutes the stochastic nature of evolution?

Yet it is observable that every temporary phase of evolution is a start-state of further evolution.

And it is observable that all objects and processes and natural laws in the universe, are - since singularity - products of evolution and are themselves continuously further evolving. Everything in the cosmos is fractal, rehappens on many scales, and is continuously evolving. Each and every system in the universe continuously evolves within the total universal evolution and all the systems' evolutions are intertwined.

And it is also observable that all evolutions are fueled by culture, culture being the totality of ways of the system's dealing (reaction to, manipulation of, exploitation of) with its environment.

Suggesting,

Dov Henis

PS: Present state (March 2008) of the stock market appears to point at the relationship between stocks and stochastic... DH
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Zarkov
Posted: Mar 29 2008, 09:28 AM


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QUOTE
Science Must Refresh Concept Of Evolution


oh it has, it has

Evolution just does not exist.... what next ?

LIFE's purpose is to reproduce.. survive .... and just BE.

Is there any other purpose ?

all invention is to aid survival.... everything we do was/is to survive

now LIFE is flowering, LOL...... y'all are totally redundant... it will seed... and you ain't invited to the party !!!


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HenisDov
Posted: Mar 29 2008, 09:47 AM


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QUOTE (Zarkov @ Mar 29 2008, 09:28 AM)

oh it has, it has

Evolution just does not exist.... what next ?

LIFE's purpose is to reproduce.. survive .... and just BE.




Thanks for the revelation.

Would greatly appreciate the scientific references...

DH
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Zarkov
Posted: Mar 29 2008, 08:29 PM


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QUOTE
Would greatly appreciate the scientific references...


you would like all the pieces of the puzzle

LOL, in the face of religion, and political propaganda

well unless you are a geneticist or a biochemist you would have an uphill battle

so let me just say as a professional, that summery is my take, as well as many others, including the opinion of the first person to unravel DNA.

However the information is scattered for the knowledgeable unbiased mind to appraise, you should do some reading

maybe at my site
see thread
LIFE- the super-organism. many unclaimed gems there


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HenisDov
Posted: Mar 30 2008, 11:20 AM


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QUOTE (Zarkov @ Mar 29 2008, 08:29 PM)

...well unless you are a geneticist or a biochemist you would have an uphill battle...



Grateful for your kind invitation.

However, I regret not being able to enjoy it since from your invitation I conclude that the contents would be beyond my understanding capability.

Respectfully,

Dov Henis
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HenisDov
Posted: Mar 30 2008, 06:53 PM


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Chirality In Life Still Awaits Elucidation

A. From "...key to life before its origin on Earth?"
http://www.physorg.com/news123440279.html#tab

When scientists synthesize these molecules in the laboratory, half of a sample turns out to be “left-handed” and the other half “right-handed.” But the amino acids that are the building blocks of terrestrial proteins are all “left-handed,” while the sugars of DNA and RNA are “right-handed.” The mystery as to why this is the case, “parallels in many of its queries those that surround the origin of life...”

Thanks to the pristine nature of this meteorite, we were able to demonstrate that other extraterrestrial amino acids carry the left-handed excesses in meteorites and, above all, that these excesses appear to signify that their precursor molecules, the aldehydes, also carried such excesses,” Pizzarello said. “In other words, a molecular trait that defines life seems to have broader distribution as well as a long cosmic lineage.”

B. From "Allosteric, chiral-selective drug binding to DNA"
http://www.pnas.org/cgi/reprint/97/22/12032.pdf

(Allosteric: of, relating to, undergoing, or being a change in the shape and activity of a protein, as an enzyme, that results from combination with another substance at a point other than the chemically active site)

DNA is polymorphic and exists in a variety of distinct conformations. Duplex DNA can adopt a variety of sequence-dependent secondary structures that range from the canonical right-handed B form through the left-handed Z conformation. Multistranded triplex and tetraplex structures are now known to exist. All of these unique conformations may play important functional roles in gene expression.

C. Chirality in life still awaits elucidation

First, reasearch findings should be stated scientifically correctly. In A above NOT "a molecular trait that defines life seems to have broader distribution as well as a long cosmic lineage”, but YES "a molecular conformation dominant in Earth life may have broader distribution and additional cosmic presence.”

Next, re in A above "the mystery as to why this is the case":

My conjecture about the probable reasons for the prevailing chirality:

Darwinian evolution started at life's day one, with the genesis of the first organisms, the replicating oligomers, pre-archaea genes. It started under yet-unknown energetic conditions, by a serendipitous accident, with oligomeric (RNA?) conformations, in a soup containing all their essential molecular progenitors. These Conformations happened to absorb the amounts of energy enabling their polymerization, to lengths precipitated as determined by the nature and conditions of the soup.

The sugars and the nitrogen-based compounds that, together with the phosphates, are the components of the genes-organisms, are chiral. There probably is an energetic advantage in homochirality and chiral homogeneity for the self-replication of biopolymers.

This serendipitous accident set up a matrix-field of energy with a potential extended between its source, the sun radiation and the precipitating organisms. This was the genesis of the ongoing formation and maintenance of Earth's biosphere.

And since the biosphere started it could only evolve in more favorable energetic directions and towards stabler components. Survival. After all this is evolution.

But this is a conjecture. Chirality in life still awaits elucidation...


Dov Henis
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HenisDov
Posted: Apr 2 2008, 12:48 PM


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"Natural Selection Speeds Up Speciation",
Is Science Catching Up With Us?


A.
Darwin and UBC: natural selection speeds up speciation
http://www.eurekalert.org/pub_releases/200...c-dtu033108.php


B.
physorgforum and Dov Henis: Culture Is Biology, It Imprints Genetics And Drives Evolution

http://www.physforum.com/index.php?showtop...65&#entry323376

http://forum.physorg.com/index.php?showtop...65&#entry316631


"By plain common sense it is therefore culture, the ubiqitous biological entity, that drives earth life evolution."

"Eventually it will be comprehended that things don't just "happen", "mutate" randomly in the base-prime organism, genome, constitution; the capability of the base-prime organisms to "happen" and "mutate" is indeed innate, but things "happen" and "mutate" not randomly but in biased directions, affected by the culture-experience feedback of the second level multi-cell organisms (or the mono-cell communities)."

Dov Henis
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HenisDov
Posted: Apr 4 2008, 07:34 AM


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Age As A Variable In Genetics

Re http://www.hsph.harvard.edu/news/press-rel...on-studies.html

I wonder if biostatistics are analyzable and interpreted similarly or identically when applied to (inanimate) molecular conformations and to (living) organisms.

Studying the relationship between a gene and its expression is studying the relationship between an organism (gene) and its function (expression).

The "team of researchers" is invited to look at some links, starting with

http://www.physforum.com/index.php?showtop...65&#entry320236

and to be prepared to change comprehension of the nature of genes-genome, life, and life-evolution.


Respectfully,

Dov Henis
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