uh oh -

NONSENSE alert!

It's very disappointing that Dr. Axe snuck this somewhat NON-scientific, paper:

J. Mol. Biol (2004) 341, 1295 - 1315.

Into the thick of things.

Firstly, there is NO comment whatsoever in the paper (I read the whole silly thing) about ID. Secondly, not one citation in the reference index is made to hypervariability in antigen binding loops. Iow, all he did was specifically focus on non-variable areas and then say, 'see, I told you so'.

So, here's a very basic breakdown of how proteins work. The protocol goes: DNA -> RNA -> proteins. DNA has VERY redundant spots where ANY variation causes very catastrophic results and then areas where mutation can and does occur, usually w/o deleterious effects (i.e. how one of the 2 nodes of evolution work) and sometimes w/ positive results.

I cite (again, as in previous threads) the phthalidomide scares in the late 1950s/early 60s. I cite this for 2 reasons: 1) it show that as late as the 60's humans had NO idea about chiral chemistry (the fact that chemicals can have left-handed or right-handedness to them) and 2) that some areas of our genome are VERY sensitive to chemical intrusion and others are not.

Seriously, do we want mutation to occur in areas of our genomes that turn on, say, finger production/apoptosis? or, what about brain growth? I cite another awful tragedy of human hubris. Caesium-137 coming from Chernobyl has caused a horrific increase in babies born in nearby towns w/ their brains/dura mater growing outside of their skulls and the babies survive - of course, in a pain-ridden, vegetative state.

Anyway, proteins are VERY similar to DNA infrastructure, in that certain areas of the proteome are VERY sensitive to changes and certain areas (like antigen binding loops - the spots where antigens bind and the 2 sides of the immune system (humoral and complement) deconstruct the antigen and build antibodies to confront the foreign substance. These areas are hypervariable, where mutability is a cornerstone of how ALL OF OUR IMMUNE systems work.

The fact that Axe 1) decided to focus on these nonvariable areas and seems to have deliberately excluded the well-known mol. biol. data that certain areas are variable and others are not is just bad science 2) seems to think that stochastic sequences will replace existing sequences is again, bad hypothesis. Again, now that stochastics have a huge library of mathematical tools (see chaos theory), he never employs one - not one.

Note very crucially that he did absolutely NO free-energy calculations or MD simulations. Ok, the low-down on protein folding: Atoms in proteins fit together in secondary, tertiary and quaternary structture because they achieve local energy minima in terms of the electron clouds around the atoms. This is absolutely no easy task, since then you have to take into account pH, solvation effects, the dual (amphophilic) nature of water, etc. etc. etc.

His citations using "exponential" terminology is true ONLY if you calculate probabilities like you do winning the lottery. We already know this is NOT the case, since proteins, by definition of being a protein, have superstructures (2ndary, tertiary, etc.).


soloved,

you really need to analyze the completely moronic citations you post, particularly on a website like this one, where people criticallyID read what you post. I'm guessing that adoucette will handily deconstruct the other total bullsh&t you post. Seems like s/he has already done an excellent job.

I have to ask you:

Why do people like you think you have the righteous privilege to impose your beliefs on everyone else? Just like the Muslims, you fanatics are all so abhorrent. The circumstances of how you fkn nutjobs do it is irrelevant. Like justice Roy Moore in Alabama asserting that since "we all know" our canon of law in the US was derived from biblical origins, he had no problem placing monster marble tablets of the 10 Commandments in the Alabama Supreme Court. The end result is the same. You trample on other peoples' positions in almost every aspect of life, just b/z you arrogant f&cks "think" we need saving - even though the Bible states (I loooove this statistic - shows what small brains the authors had back then) that only 144K people will be allowed into heaven.

this is definitely NOT a question of equal representation in schools, mind you, since ID is just arrogant humans not understanding their own species' feeble-mindedness and, as easily noted above.

If our knowledge of the simple little electron is only 103 years old, why do you think Evolution as a model is complete?????????? We still don't even know what gravity is!!! How about asceptic technique in surgery? Surgeons were STILL not even washing their hands as late as 1900! Jeez, and we have known about microbes since 1673 w/ Anton von Leeuwenhoek and doctors couldn't put 2 and 2 together for another 200 years??

-w/ ignorant, subhuman monsters like you and JerryDuke around, I am so skeptical about the survival of the human race....